MOA of fibrates - quansar

[ArchivalUser]

1. enzyme break down
2. transcription downregulation
3. decrease lipoprotein synthesis
4. hormone regulation
5. receptor downregulation

answer and why??

[ArchivalUser]

3..

[ArchivalUser]

sorry, option 2 has typo

it should be transcription upregulation

))

[ArchivalUser]

333

[ArchivalUser]

sorry change ans its 222,transcription upregulation

[ArchivalUser]

3.fibratesexert their lipid lowering effect by activating the peroxismal proliferator activator receptor alfa(PRAR).fibrates derivatives useful for decreasing TG.they inc the action of lipoprotein lipase causing degradation of lipoprotein.

[ArchivalUser]

But fenofibrate mediates its effects in part via activation of the specific transcription factors ppar alpha.which control the transcription of many genesinvolve in the regulation of fatty acid and cholesterol.

[ArchivalUser]

222...upregulates trans of lip. lipase....u gave away the answer quansar...:))

[ArchivalUser]

fido, yes I do. )


2 is the correct answer, upregulation of transcription via PPAR-Alpha.

now who can tell me which famous drug activates PPAR-Gama???

[ArchivalUser]

pioglitazone,,,all the thiolidinediones