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A person eats cookies made with coconut oil. The predominant fatty acid in the triglycerides contained in the coconut oil is lauric acid, which is a saturated 12-carbon fatty acid. Starting with free lauric acid within the mitochondria, what is the net energy yield in high-energy phosphate bonds from each molecule of lauric acid?
A. 83
B. 85
C. 95
D. 97
E. 110
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D 97 ATP . 12 C yield 6 acetyl coA which makes 72 ATP
5 NADH 15 ATP
5 FAD 10ATP
is it like that????
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D. 95
From the 12C fatty acid we end up getting 6 molecules of Acetyl Co A. This produces a nett of 23 ATP. From each molecule of Acetyl co A, each turn of beta oxidation produces 12ATP.
Therefore.. From oxidation 6x12=72 ATP
Prior to oxidation to produce ACetyl Co A= 25 ATP
Total is 95 ATP. or so i think. Where is this question from biochem2?
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sorry, my mistake, i think the nett production of ATP from breakdown for lauric acis bonds is only 23 ATP . some ATP is used for the conversion of FA to FA CoA by FA Co Synthetase right?
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The correct answer is C.Here is the calculation you need to perform.
Activation of the laurate requires two high-energy phosphate bonds as ATP is converted to AMP. The 12 carbon lauryl CoA is then split 5 times to produce 6 acetyl CoAs, and 5 ATPs (obtained from 1 FADH2 and 1 NADH), that are produced by each β-oxidation cycle. The resulting 6 acetyl CoA each produce 12 ATP equivalents (one is GTP, which is converted to ATP) when processed by the citric acid cycle.
u were right lucid interval. this is from kaplan q bank. i was clueless abt it. ty for the explanaiton.
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i understand that 12C produces 6 acetyl co A and 72 ATPs. can u explain rest of the part.thnx
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For Beta Oxidation to begin the fatty acid must be converted to its corresponding Fatty Acyl Co A by the enzyme Fatty Aceyl Co A synthetase. This reaction requires the conversion of ATP to AMP utilizing 2 high energy bonds.
hence you have to subtract these 2 from the gross production of ATP which is 97 (from 6 actely co and 5 NADH and % FAHD2)
hence 97-2= 95
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ok thnx lucid,thats how i ended up makin 97.thnx