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A 34-year-old man develops pulmonary hemorrhage and glomerulonephritis. Lung biopsy with
immunofluorescence demonstrates IgG deposition along the basement membrane. These antibodies are most likely directed against which of the following types of collagen?
A. Type I
B. Type II
C. Type III
D. Type IV
E. Type X
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basement membrane type 4 collagen
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It is D, type II hyper SS
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The correct answer is D. The disease described is Goodpasture's syndrome, in which autoantibodies to
basement membrane proteins cause damage to the lungs and kidneys. Pulmonary hemorrhage (especially in smokers) and rapidly progressive glomerulonephritis are common. The characteristic autoantibody present is directed against Type IV collagen, a component of the basement membrane.
Type I collagen (choice A) is found in bone, skin, tendon, dentin, fascia, and late wound repair.
Type II collagen (choice B) is found in cartilage (including hyaline cartilage), the vitreous body of the eye, and the nucleus pulposus of the intervertebral disk. Type III collagen (choice C) is found in skin, blood vessels, uterus, fetal tissue, and granulation tissue.
Type X collagen (choice E) is found in epiphyseal plates.
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dd is correct Goodpasture's syndrome
