Posts: 3,675,934
Threads: 734,342
Joined:
Sep 2021
Reputation:
5
why its better to give unfractionated heparin during labour and delivery than LMWH?
why its better to give LMWH during pregnancy than unfractionated heparin?
Posts: 3,675,934
Threads: 734,342
Joined:
Sep 2021
Reputation:
5
Unfractionated heparin:
- has a high molecular weight which precludes transplacental transfer.
- devoid of known teratogenic risk and does not anticoagulate the fetus
so used in labour and delievery.
BUT
- relative difficulty of maintaining a stable therapeutic response
- inconvenience of parenteral administration,
- complications of heparin-induced thrombocytopenia
Because of this reasons Unfractionated heparin not used in pregnancy
LMW heparin may resolve the difficulty in achieving a sustained, stable therapeutic response and may reduce the inconvenience of parenteral administration (increased bioavailability and a longer half-life)
Posts: 3,675,934
Threads: 734,342
Joined:
Sep 2021
Reputation:
5
good to know.
so thrombocyopenia risk is lesser with LMWH than unfractionated?
would you mind to share the source of your answer harry?
Posts: 3,675,934
Threads: 734,342
Joined:
Sep 2021
Reputation:
5
yes thrombocyopenia risk is low with LMWH
source of info:
Harrison's principle of Internal Medicine
uptodate.com