09-11-2009, 06:56 AM
A 34-year-old male with Hodgkin's disease is treated with the adriamycin, bleomycin, vinblastine, and decarbazine (ABVD) regimen. What is the mechanism of action of vinblastine?
A. Scission of DNA strands
B. Inhibition of dihydrofolate reductase
C. Inhibition of enzymes involved in purine metabolism
D. Prevention of assembly of tubulin dimers into microtubules
E. Inhibition of topoisomerase
A. Scission of DNA strands
B. Inhibition of dihydrofolate reductase
C. Inhibition of enzymes involved in purine metabolism
D. Prevention of assembly of tubulin dimers into microtubules
E. Inhibition of topoisomerase