*how do homocysteine contribute to vasculardisease - samomcos

[ArchivalUser]

anybody have an idea as to the MoA?

[ArchivalUser]

i just know that it predisposes to thromboses

[ArchivalUser]

homocysteine degrades and inhibits the formation of the three main structural components of the artery, collagen, elastin and the proteoglycans. Homocysteine permanently degrades cysteine disulfide bridges and lysine amino acid residues in proteins, gradually affecting function and structure. Simply put, homocysteine is a 'corrosive' of long-living proteins, i.e. collagen or elastin, or life-long proteins, i.e. fibrillin.

Elevated levels of homocysteine have been linked to increased fractures in elderly persons. The high level of homocysteine will auto-oxidize and react with reactive oxygen intermediates and damage endothelial cells and has a higher risk to form a thrombus.Homocysteine does not affect bone density. Instead, it appears that homocysteine affects collagen by interfering with the cross-linking between the collagen fibers and the tissues they reinforce.

source..wikipedia

[ArchivalUser]

thanks mleone...that was enlightening!

[ArchivalUser]

https://www.usmleforum.com/6MMN8Q