04-09-2010, 01:57 AM
A 26 year old woman presents with increasing fatigue and malaise. She states that recently she develops a red facial rash whenever she goes outside on a suny day. Physical examination finds that she is afebrile, but her bp is slightly increased and slight peripheral edema is found. Lab evaluation finds slightly elevated BUN and creatinine, while dipstic examination of her urine reveals slight proteinuria with microscopic heamturia. Very rare granular and red cells casts are seen. lab examination is also positive for serum antinuclear antibodies, one of which is anti-double stranded DNA. A renal biopsy reveals diffuse proliferative GN and diagnosis of class IV lupus nephritis is made. Which of the following description best describes the histologic appearence of the nephritis mentioned?
A. Mesangial deposits form a 'holly leaf' pattern
B. Positive immunofluorescence forms a ' string of popcorn' pattern
C. Splitting of basement membrane forms a 'tram track' pattern
D. Thickening of basement membrane forms ' spike and dome' apperance.
E. Thickening of the glomerular capillaries form ' wire and loop apperance"
A. Mesangial deposits form a 'holly leaf' pattern
B. Positive immunofluorescence forms a ' string of popcorn' pattern
C. Splitting of basement membrane forms a 'tram track' pattern
D. Thickening of basement membrane forms ' spike and dome' apperance.
E. Thickening of the glomerular capillaries form ' wire and loop apperance"