trig>200 ldl>200 2 risk factors - lascrusesdoc

[ArchivalUser]

tx
1)ator
2)atorv+niaci
3)atorva+gem

[ArchivalUser]

and what are those two risk factors ?

but will go for HMG-CoA only as if u want TAG

[ArchivalUser]

risk factors are family history of cad and age.

[ArchivalUser]

atorva only, wil take care of both LDL N TAG
TAG isnt a big issue here and atorva alone will bring it much down, no need to add extra drug for it risking added adverse drug effecs

[ArchivalUser]

tg>200 and ldl>200
ans is 3333333)atorva+gem

tg>200 needs gemfibrozil,thats a indication

[ArchivalUser]

my ans:

1 + nonpharmacologic measures.

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here is my hard work from CMDT, ATPIII and Washington manual:

management of high TG with or without high LDL:



1) triglycerides of 400 mg/dL or less
and elevated LDL cholesterol levels ------- statin + nonpharmacologic measures.


2 if the triglycerides are above 400 mg/dL despite adequate dietary modifications and exercise, the choice

a statin at higher doses,
gemfibrozil,
fenofibrate,
niacin,
or omega-3 fatty acids.



3) For patients with triglycerides over 1,000 mg/dL-------- DOC: fibrates and niacin

If LDL cholesterol levels remain high after the triglycerides are lowered,
combination therapy -------------- S/E: myopathy and rhabdomyolysis

----statin+ niacin (better side effect profile than other)
---or, statin + fibrinate

The combination of a fibrate and statin should be avoided in patients with

renal insufficiency,
congestive heart failure,
severe debility,
or other conditions,
which may affect the metabolism of medications.




Patients whose triglycerides remain above 200 mg/dL
---------- non-HDL cholesterol evaluated as a secondary goal of therapy
If non-HDL cholesterol is not at goal, therapeutic lifestyle changes should be emphasized.
The dose of statin can be increased or a second medication such as ezetimibe can be added.

[ArchivalUser]

I am mentioning from a kaplan q bank ques ...........

[ArchivalUser]

Thanks Meti for sharing such concise info

@lascrusesdoc
try remember by heart what Meti said as i got exactly similar question on real exam, though i dont remember TAG value whether they were 400+ or - , but i knew it from my year of IM practice back home when to give single/two drug therapy and never read it from a book, wasnt sure thats why didnt clarify it to you that time, but its good Meti did and wil help guys in exam plus in real life practice.
GL guys