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A 28 year-old male of Jewish descent presents with abdominal pain, diarrhea and fever. Physical exam reveals a tender abdomen and a perianal fistula. A biopsy reveals chronic inflammation in the small intestine involving all layers of the intestinal wall. This patient may be treated with a monoclonal antibody which blocks which of the following cytokines?
A. IL-3
B. IL-5
C. IL-8
D. IFN-Beta
E. TNF-Alpha
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eee, looks like Crohn dz.
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bbbb ulcerative colitis with Th2 effect to be blocked
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it's not UC, since it's transmural inflammation, plus very common fistulas as a compication
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EE
pt.got Crohn dis.
Monoclonal Ab
-Infliximab
-Adalimumab
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This is a classical presentation of Crohn's disease. While the etiology of this disorder is still unknown, TNF-Alpha seems to play a key role. Blocking TNF-Alpha with a monoclonal antibody (such as Infliximab or Adalimumab) causes disease remission in a large number of Crohn's patients.
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guys now UC is only mucosa and submucosa? while crhons is transmural? I think fa 2009 made a mistake here then!! ill check it when I go home.
