==Maryam,Sarim and others,plz help==NBME2 - usmleshik

[ArchivalUser]

Hepatitis B virus is the major cause of hepatocellular carcinoma. Replication of its nucleic acid is schematically depicted:

Partial Double-stranded DNA --(1)--> double-stranded DNA --(2)--> single-stranded RNA --(3)--> single-stranded RNA and DNA hybrid

The enzyme involved at step 2 is most likely to be

A) DNA ligase
B) DNA polymerase
C) reverse transcriptase
D) RNA ligase
E) RNA polymerase

HI friends,i need ur help....why right anw is c?...my anw is E

[ArchivalUser]

bump...

[ArchivalUser]

bump...

[ArchivalUser]

the right answer is or should be E... C is not the right answer : ... it would be reverse transcriptase in the cytoplasm of Hep B where it will make DNA from mRNA, after its done making the functional proteins that need to be sent out of the cell ....

idk why option C is the correct answer...

http://www.youtube.com/watch?v=sVpiXaEMs7I

http://www.wjgnet.com/1007-9327/13/48.pdf : Page 49

http://pathmicro.med.sc.edu/virol/hepatitis-virus.htm check section HEP B replication...


hope this clarifies ...... if anyone else has a better explanation cause im sure HEP B uses HOST MECHANICS until its in the cytoplasm and has made its own RNA polymerase for REVERSE TRANSCRIPTION....

[ArchivalUser]

Anybody else

[ArchivalUser]

EEE host RNA polymerase II

1-bacterial DNA polymerase (that complete the partial DNA strand inside host cell nucleus)

2-Host RNA polymerase II (forms the ssRNA)

3-bacterial DNA polymerase (also act as reverse transcriptase)


is posted by Sarim

[ArchivalUser]

Maryam,Zen78.....thanks a lot....