10-08-2014, 01:11 PM
MBME 4 Q.
The P50 is defined as the partial pressure of oxygen (in mm Hg) required to saturate half of the hemoglobin O2 binding sites in a sample of whole blood. In blood from a healthy adult, the P50 is approximately 26 mm Hg when equilibrated with a mixture of 16% O2, 5% CO2, 79% N2. Which of the following manipulations will cause the P50 of the sample to increase?
A. Cooling the blood from 37C to 20 C
B. Depleting its erythrocytes of 2,3-bisphosphoglycerate
C. Equilibrating it with 16% O2,12% CO2, 72% N2
D. Increasing its pH by 0.3 units using NaOH
E. Mixing it 1:1 with cord blood from a newborn
Plz Explain ur answer. thanks
The P50 is defined as the partial pressure of oxygen (in mm Hg) required to saturate half of the hemoglobin O2 binding sites in a sample of whole blood. In blood from a healthy adult, the P50 is approximately 26 mm Hg when equilibrated with a mixture of 16% O2, 5% CO2, 79% N2. Which of the following manipulations will cause the P50 of the sample to increase?
A. Cooling the blood from 37C to 20 C
B. Depleting its erythrocytes of 2,3-bisphosphoglycerate
C. Equilibrating it with 16% O2,12% CO2, 72% N2
D. Increasing its pH by 0.3 units using NaOH
E. Mixing it 1:1 with cord blood from a newborn
Plz Explain ur answer. thanks