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A 38-year-old man presents to the emergency room with multiple arm and leg fractures following a minor fall. Physical examination reveals a slight weakness of facial muscles on the left. A complete blood count shows a mild anemia. X-ray studies reveal a generalized bony widening with partial obliteration of marrow spaces. The patient's disorder is most likely due to abnormal function of which of the following cell types?
A. Granulocytic stem cells
B. Megakaryocytes
C. Plasma cells
D. Osteoblasts
E. Osteoclasts
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E. Osteopetrosis and osteoclasts have abnormal function
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plasma cells....MM...i think correct me if i am wrong?
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abnormal function of plasma cells
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The correct answer is E.
Osteopetrosis (Albers-Schonberg disease) - group of hereditary diseases --- impaired osteoclast function leads to reduced bone resorption.
- Abnormal osteoclasts frequently are enlarged, with bizarre shapes
- Bones become thick and brittle
- Anemia secondary to marrow loss
- CN deficits secondary to narrowing of bony ostea
An autosomal recessive, severe form of the disease --- death in childhood.
A relatively benign, autosomal dominant form --- in adulthood.
