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why not cold antibody ? - newboy
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07-31-2006, 08:43 AM
60 y/o pt. with lymphoma complains of weakness, exertional SOB, easy fatigability, HGb-10, Hct-30, Ret. count -3.5, LDH-400,, + spherocytes, + Coombs test for IgG, most likely DX
1. cold Ab Hemolytic Anemia 2. hereditary sperocytosis 3. autoimmune hemolytic anemia *4. warm Ab Hemolytic anemia
07-31-2006, 09:38 AM
In cold ab hemolytic anemia, the hemolysis occurs only when the patient is exposed to a cold environment (or so I think i've read) Since the q doesnt mention anything like that, warm Ab hemolytic an wud be more likely.
07-31-2006, 10:44 AM
cold antibody anaemia is caused by IgM antibodies and warm by IgG and our patient has IgG antibodies.
07-31-2006, 11:44 AM
Autoimmune haemolytic anaemia may be due to:
warm reactive IgG autoantibodies cold reactive IgM autoantibodies / cold haemagglutin disease drug provoked haemolytic anaemia complement activating IgG of paroxysmal cold haemoglobinuria |
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