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hiv - veronica92
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08-02-2006, 05:39 PM
A 34 yr old hiv pos man is brought to the er with hypotension,tachycardia , fever and s/s of severe shock. His blood culture is pos for aspergillus. Which of the following factors is crucial in the pathogenesis of this type of shock.
a C3a C5a b IF GAMMA c. TNF dProstaglandinE e.Histamine
08-02-2006, 05:49 PM
Well done cd45 n voice..The reason is macrophages respond to LPS of gram neg bact by producing TNF which sets into motion the release of other cytokines IL-1,6,8...generating the pic of septic shock.
I was confused with IF gamma but then depletion of T cells in AIDS explains the absence of this mech Any inputs..have I faltered somewhere.
08-02-2006, 06:08 PM
i'll go with..B,aspergillus ---extracellular pathogen,..T cell related..need IF gamma for cytotoxic CD8 action.in HIV CD4 count depletes not CD8....PLEASE CORRECT ME IF I'M WRONG!
08-02-2006, 06:11 PM
But raptor isn't TH1 cell required for IF gamma prod.
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