HOX genes and limbs - progesterone

[ArchivalUser]

3. An infant is born with absence of the ulna and radius and malformations of the carpals and hand. Recent studies show that unique limb segment identities are encoded by HOX genes as follows (scapula - HOX9; humerus - HOX9HOX10; ulna,radius - HOX9HOX10HOX11; proximal carpals - HOX9HOX10HOX11HOX12; distal carpals, metacarpals, phalanges - HOX9HOX10HOX11HOX12HOX13). Therefore, disruption of expression of which of the the following HOX gene families would most likely account for this anomaly?
A. HOX9
B. HOX10
C. HOX11
D. HOX12
E. HOX13

[ArchivalUser]

we have done this one )

[ArchivalUser]

HOX 11 ( A and D) mutations ----> forearm

HOX 13( A and D) mutation ------> hand id go with Hox 13 since that also causes hand foot genital syndrome and synpolydactyly...

[ArchivalUser]

guess i missed it earlier then!!

[ArchivalUser]

C. HOX 11