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A 49-year-old woman with a history of moderate hypertension and grand-mal seizures presents with arthralgia, arthritis, and fever. She complains of photosensitivity, nausea, and facial flushing. Physical examination reveals a blood pressure of 114/66 mm Hg and a resting pulse of 108/min. Laboratory studies reveal a positive antinuclear antibody test. The patient™s symptoms are most likely side effects of which of the following?
A. Amiodarone
B. Hydralazine
C. Hydrochlorothiazide
D. Phenytoin
E. Procainamide
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steady....good job recognizing other drug causing SLE type synd....
Ans is B though.
The correct answer is B. The patient has an SLE-like syndrome as a result of the antihypertensive agent hydralazine. This is confirmed by the positive antinuclear antibody test. Although phenytoin (choice D, an antiseizure medication) and procainamide (choice E, a class IA antiarrhythmic), can also cause an SLE-like syndrome, there are no findings to suggest these agents were used. Furthermore, the patient™s relatively low blood pressure and resting tachycardia suggest she has been treated with an antihypertensive agent. Hydralazine also can cause photosensitivity, nausea, and facial flushing.
