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A 40-year-old female with Graves' disease was recently started on methimazole. One month later she comes to the clinic for a routine follow-up. She notes some low-grade fevers, arthralgias, and general malaise. Laboratories are notable for a mild transaminitis and a glucose of 150 mg/dL. All the following are known side effects of methimazole except
A. agranulocytosis
B. rash
C. arthralgia
D. hepatitis
E. insulin resistance
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Methimazole is generally well tolerated. Rash, arthralgia etc most common. While agranulocytosis, thrombocytopenia in some patients... Extreme cases...hepatitis, Hep. necrosis leading to GI bleed d/t varices and death ( very very rare )
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shigella you have a big brain, you dont need any1 else s brain
The answer is E.
Chapter 320. Disorders of the Thyroid Gland
The thionamides propylthiouracil (PTU), carbimazole, and methimazole are the main antithyroid medications used for the treatment of hyperthyroidism. They all inhibit the function of thyroid peroxidase, reducing oxidation and organification of iodide. PTU also inhibits the deiodination of T4 to T3. PTU has a half-life much shorter than that of methimazole. Rash, urticaria, fever, and arthralgias are common side effects, occurring in up to 5% of these patients. They may resolve spontaneously. Major side effects are rare but include hepatitis, agranulocytosis, and a systemic lupus erythematosus (SLE)-like syndrome. If major side effects are noted, it is essential that antithyroid medications be stopped
