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cervical lymphadenopathy - saonew
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10-31-2006, 05:44 AM
A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?
(A) bcr-c-abl (B) bcl-2 activation © c-myc activation (D) t(8, 14) (E) t(9, 22)
10-31-2006, 06:10 AM
The correct answer is B. Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas.
An abl-bcr hybrid (bcr-c-abl; choice A) and t(9, 22) translocation (choice E) are associated with chronic myeloid leukemia (CML). c-myc activation (choice C) and t(8, 14) (choice D) are associated with Burkitt lymphoma. |
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