mcq11,12,13 - sinagrida

[ArchivalUser]

11. A cytokine produced primarily by monocytes and macrophages

a) Interleukin 1
b) Interleukin 2
c) Interleukin 4
d) Interleukin 8
e) Interleukin 10

12.An amino acid that stimulates the acute phase response, leading to an increase in C-reactive protein a

a) Interleukin 1
b) Interleukin 2
c) Interleukin 4
d) Interleukin 8
e) Interleukin 10

13.A cytokine that causes stimulation of IL1
a) Interleukin 1
b) Interleukin 2
c) Interleukin 4
d) Interleukin 8
e) Interleukin 10

[ArchivalUser]

11a
12-don get it (il8??)
13 c

[ArchivalUser]

11a
12-don get it (il8??)
13 c

[ArchivalUser]

Most of them are confusing

11.The correct answer is D

Tumor necrosis factor alpha is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues. It shares many properties with another cytokine - interleukin 1. It is not unique to RA, but occurs in many inflammatory diseases, and also as a response to endotoxins from bacteria for example.

12.The correct answer is D

TNF alpha is released by white blood cells, endothelium and several other tissues in the course of damage, e.g. by infection. Its release is stimulated by several other mediators, such as interleukin 1 and bacterial endotoxin. It has a number of actions on various organ systems, generally together with interleukins 1 and 6:
On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators. It attracts neutrophils very potently, and helps them to stick to the endothelial cells for migration. On macrophages: stimulates phagocytosis, and production of IL-1, oxidants and the inflammatory lipid, prostaglandin E2 (PGE2). On other tissues: increasing insulin resistance. A locally increasing concentration of TNFα will cause the cardinal signs of Inflammation to occur: Heat, swelling, redness and pain.

13.The correct answer is D

The receptors for the Tumor necrosis factor are on several mononuclear cells, in the synovial membrane, as well as the peripheral blood and synovial fluid. There are also soluble receptors - receptors that are free in solution. These are shed from mononuclear cells. Increased soluble receptors are seen in RA, SLE, Systemic sclerosis, MCTD, RA, and to a certain degree OA, although the latter is less than the levels in RA. The soluble TNF receptors block the TNF by mopping up and blocking the levels of TNF, so that less is available to activate the mononuclear cells. They thus act as natural inhibitors. The incidence and extent of the levels of the soluble receptor correlates with disease activity.

[ArchivalUser]

Most of them are confusing

11.The correct answer is D

Tumor necrosis factor alpha is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues. It shares many properties with another cytokine - interleukin 1. It is not unique to RA, but occurs in many inflammatory diseases, and also as a response to endotoxins from bacteria for example.

12.The correct answer is D

TNF alpha is released by white blood cells, endothelium and several other tissues in the course of damage, e.g. by infection. Its release is stimulated by several other mediators, such as interleukin 1 and bacterial endotoxin. It has a number of actions on various organ systems, generally together with interleukins 1 and 6:
On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators. It attracts neutrophils very potently, and helps them to stick to the endothelial cells for migration. On macrophages: stimulates phagocytosis, and production of IL-1, oxidants and the inflammatory lipid, prostaglandin E2 (PGE2). On other tissues: increasing insulin resistance. A locally increasing concentration of TNFα will cause the cardinal signs of Inflammation to occur: Heat, swelling, redness and pain.

13.The correct answer is D

The receptors for the Tumor necrosis factor are on several mononuclear cells, in the synovial membrane, as well as the peripheral blood and synovial fluid. There are also soluble receptors - receptors that are free in solution. These are shed from mononuclear cells. Increased soluble receptors are seen in RA, SLE, Systemic sclerosis, MCTD, RA, and to a certain degree OA, although the latter is less than the levels in RA. The soluble TNF receptors block the TNF by mopping up and blocking the levels of TNF, so that less is available to activate the mononuclear cells. They thus act as natural inhibitors. The incidence and extent of the levels of the soluble receptor correlates with disease activity.

[ArchivalUser]

thanks for the Qs. You say here that IL-8 is TNF-alpha?????? DONT THINK SO!

[ArchivalUser]

thanks for the Qs. You say here that IL-8 is TNF-alpha?????? DONT THINK SO!

[ArchivalUser]

option D are IL-8 for your Qs not TNF-alpha!!!!!!
IL-8 is a CXCL, tnf-A IS A DIFFERENT STORY....is confusing

[ArchivalUser]

option D are IL-8 for your Qs not TNF-alpha!!!!!!
IL-8 is a CXCL, tnf-A IS A DIFFERENT STORY....is confusing

[ArchivalUser]

You are right but that's the answer i had on the notes
Sorry to confuse you
I got confused myself