Mixing study - janfeb

[ArchivalUser]

Can someone please explain mixing study and why and when do v use it? Ultimately we do have to do the factor assay to diagnose... isnt it??

[ArchivalUser]

Mixing study is done to knw whether factor 8 def is congenital or acuquired

The PTT mixing study is indicated when the PTT is prolonged in the absence of heparin therapy. Patient plasma is mixed with normal plasma and the PTT is repeated. If the mixture's PTT result does not correct, the patient may have an inhibitor. There are specific inhibitors such as anti factor VIII, associated with bleeding, and lupus anticoagulants, associated with thrombosis. If the mixture's PTT result does correct, the patient may have a coagulation factor deficiency.

[ArchivalUser]

Writing book you are excellent, I feel like I should BOW to you. Your explainations are gr8 no kidding:

Which condition will it be the first test to do and what are the conditions if its normal and what are if abnormal?

[ArchivalUser]

so if v rgiven a patient with heamarthrosis etc, do v do mixing study first andthen followed by factor assay if abnormal?