03-23-2007, 06:14 AM
A 61-year-old woman with hypertension, type 2 diabetes mellitus, ischemic cardiomyopathy, and chronic renal insufficiency reports pain in her right knee. Her blood pressure is 140/84 mm Hg, and her pulse is 70 bpm. Because of tenderness and effusion in the knee joint, the patient is prescribed celecoxib 200 mg once daily. After 14 days of therapy, she reports dyspnea, increased swelling in the lower extremities, and fatigue. Blood pressure is now 188/100 mm Hg, blood urea nitrogen (BUN) is 67 mg/dL (baseline, 41 mg/dL), and serum creatinine level is 3.9 mg/dL (baseline, 1.9 mg/dL). Which of the following is the most likely mechanism by which celecoxib caused acute renal failure?
1..Acute papillary necrosis with renal obstruction
2..Acute tubular necrosis from drug-induced nephrotoxicity
3..Drug reaction causing allergic interstitial nephritis
4..Hemodynamic renal insufficiency from loss of compensatory prostaglandins induced by cyclooxygenase-2 inhibition of celecoxib
1..Acute papillary necrosis with renal obstruction
2..Acute tubular necrosis from drug-induced nephrotoxicity
3..Drug reaction causing allergic interstitial nephritis
4..Hemodynamic renal insufficiency from loss of compensatory prostaglandins induced by cyclooxygenase-2 inhibition of celecoxib