03-23-2007, 07:54 PM
Acute attack:
Rx: colchicine or Indomethacine/Ibuprofen
Recurrent attack while taking colchicine,
what is next step : do 24 hr urnary uric acid level, and if
a. >800 mg/day: Over production. Use Xanthine oxidase inhibitor, Allopurinol
b. If <800 mg/day: undersecretion. Use Probenecis, which enhances urinary excretion of uric acid.
Rx: colchicine or Indomethacine/Ibuprofen
Recurrent attack while taking colchicine,
what is next step : do 24 hr urnary uric acid level, and if
a. >800 mg/day: Over production. Use Xanthine oxidase inhibitor, Allopurinol
b. If <800 mg/day: undersecretion. Use Probenecis, which enhances urinary excretion of uric acid.