path question plz give some explanation for - telomerase

[ArchivalUser]

32 year women with breast cancer
her mother had cervical cancer at age 35, her grantfather had colon cancer at 36 yr sge her brother was recently diagmosed with lung cancer. if genetic analysis is performed , what would be the likely genotype of this individual at p53 gene locus?

A) one deleted allele
B) two deletd allele
C) two wild type allele
D) three wild type alleles
E) fusion of one p53 allele with another gene

[ArchivalUser]

B.......p53 is a tumour supressor gene...needs 2 hits...1st hit will be inherited ,2nd one wud be acquired

[ArchivalUser]

BBB
NEED BOTH COPIES OF p53 TO BE MUTATED TO HAVE CANCER

[ArchivalUser]

answer given is A
i m nt getting how it is
its frm Qbank kaplan

[ArchivalUser]

as it seems to be familial condition
inheritance of only one mutant or deleted allele will b present in all member genotype

as u all r correct only second hit is needed to cause diff cancer now
so individual genotype will will only one allele defect
and after sec hit tumor cell s will show both gene mut/deletion

hope all of u got it
Tc
and thanks

[ArchivalUser]

INDEED ONLY 1 ALLELE IS MUTATED and yuo will find this in genetical analysis, the second alele is affected by a separated muation that can be diffrent between the mebers of th family

[ArchivalUser]

thats right