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drug X has T1/2=4 hour
now pt lost one kidney,
what will be the new time to for the drug to reach steady state
1. 10 h
2. 20 h
3. 30 h
4. 40 h
5. 2 hr
6. 1 hr
7. 8 hr
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i would say double it, or maybe decreased
either 2hr or 8...
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pay attention to steady state. how many t1/2 we will need?
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so what is the ans? please explain
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ans is 4.
if Vd is the same, Cl decrease 1/2, T1/2 increase twice, which is 8h. 95% steady state is 32-40h.
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Ans 8 hours. If clearance is 50% so steady state 8 hours.
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azaaza
it means that losing one kindey will increase t1/2?
then t1/2 becomes 8h and steady state is 32-40h
is that right what you are telling? i am not very good with this subject so making sure if it is correct answer
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so to reach stady state will be 4x5=20 then is 1 kidney so X2= 40