03-26-2007, 07:19 PM
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MOA of Tamoxifen????? - biochem510
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03-26-2007, 07:23 PM
is aonist /anagonist to what ????
treta breast cancer so it is agonist estrogen, anatgonist to what ??
03-26-2007, 07:24 PM
thats what i need to know im confused as to what it is a antagonist to
03-26-2007, 07:27 PM
agonist in bone
antagonist in breast partial agonist in endometrium
03-26-2007, 08:03 PM
tamoxifen is agonist/antagonist to estrogen. its called SERMS
03-26-2007, 08:09 PM
so preventing osteoporosis , and against the breast cancer
03-26-2007, 08:46 PM
Could you tell me the difference b/w raloxifene and tamoxifen? pliz somebody help me..
I met a question who has h/o breast cancer with osteoporosis -> what is the DOC? the answer was raloxifene not tamoxifen.. what`s the differences? really wanna know~
03-27-2007, 10:53 AM
tamox....partial agoist at endometrium so inc risk of endometrial ca.rolox....antagonist t endometrium,so safer.my be age is estricting factor in u r q bach1060
03-27-2007, 12:29 PM
Tamoxifen is an antagonist against estrogen in the breast tissue and is an agonist in the endometrium.
Raloxifen doesnt have that agonist effect in the endometrium, so it's safer to give Raloxifen to post menopausal women, since there is no progesterone effect to antagonize estrogen. Where Tamoxifen can be given to pre menopausal women who have progesterone to counter effect of estrogen in the endometrium. |
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