03-31-2007, 01:53 PM
A 45-year-old man presents to a physician with back pain and facial pain.
Physical examination demonstrates coarse facial features and kyphosis.
Laboratory examination is remarkable for elevated alkaline phosphatase
. X-ray studies demonstrate skull thickening with narrowing of foramina,
and bowing of the femur and tibia. Bone biopsy reveals a mosaic
pattern of bone spicules with prominent osteoid seams. Which of
the following neoplasms occurs at an increased frequency in patients
with this disorder?
A. Astrocytoma
B. Hodgkin's lymphoma
C. Meningioma
D. Non-Hodgkin's lymphoma
E. Osteosarcoma
Physical examination demonstrates coarse facial features and kyphosis.
Laboratory examination is remarkable for elevated alkaline phosphatase
. X-ray studies demonstrate skull thickening with narrowing of foramina,
and bowing of the femur and tibia. Bone biopsy reveals a mosaic
pattern of bone spicules with prominent osteoid seams. Which of
the following neoplasms occurs at an increased frequency in patients
with this disorder?
A. Astrocytoma
B. Hodgkin's lymphoma
C. Meningioma
D. Non-Hodgkin's lymphoma
E. Osteosarcoma