pemphigus vulgaris or bullous? - laurina

[ArchivalUser]

IG-C3 at epiderm-derm jonction
thanks.(uw and Kaplan cofuse me)

[ArchivalUser]

If in epiderm-derm junction, it is bullous pemphigoid (Necolsky sign negative)
If in interepithelial junction of epidermis, it is pemphigus vulgaris (Necolsky sign positive).

[ArchivalUser]

thanks a lot:-)

[ArchivalUser]

Pemphigus:

Laboratory Findings

The diagnosis is made by light microscopy and by direct and indirect immunofluorescence microscopy. Microscopically, acantholysis is the hallmark of pemphigus, but in some patients there may be eosinophilic spongiosis initially (see micrograph). Immunofluorescence microscopy shows intercellular deposits of IgG and C3 in the epidermis. Indirect immunofluorescence microscopy detects circulating pemphigus autoantibodies that correspond with disease activity and help in management.

Pemphigoid:
The diagnosis is made by biopsy and direct immunofluorescence examination. Light microscopy shows a subepidermal blister. With direct immunofluorescence, IgG and C3 are found at the dermal-epidermal junction.

From CMDT, 2007

[ArchivalUser]

and you look at the age as well

over >60 y/o think Bullous Pemphigoid

[ArchivalUser]

Hey guys, Checkout the book "Dermatology for the USMLE" in Amazon.

Cover all derm topics for the boards, excellent source to score high. It has HIGH quality pics for every disease you may encounter in the USMLE's.

Bought it in amazon 5 months ago, it is awesome. A must have...