breast milk jaundice - zzetegn

[ArchivalUser]

pathophysiologic mechanism ?

[ArchivalUser]

The mechanism is not well understood but following factors have been suggested to play a role:


1. An unusual metabolite of progesterone (pregnane-3-alpha 20 beta-diol), a substance in the breast milk that inhibits uridine diphosphoglucuronic acid (UDPGA) glucuronyl transferase

2. Increased concentrations of nonesterified free fatty acids that inhibit hepatic glucuronyl transferase

Increased enterohepatic circulation of bilirubin due to
(1) increased content of beta glucuronidase activity in breast milk and, therefore, the intestines of the breastfed neonate and
(2) delayed establishment of enteric flora in breastfed infants

Defects in uridine diphosphate-glucuronyl transferase (UGT1A1) activity in infants who are homozygous or heterozygous for variant Gilbert syndrome promoter polymorphism

[ArchivalUser]

thanks once again . that was realy amazing

[ArchivalUser]

thanks

[ArchivalUser]

thanks man