multiple progressive leukoencephaopathy - doctorsaheb

[ArchivalUser]

can some one explain me about this disease

[ArchivalUser]

from CMDT, 2007

Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder with a propensity for affliction of immunosuppressed adults with impaired cell-mediated immunity, especially AIDS patients. Recently, natalizumab, a monoclonal antibody, against 4 integrins, with potential therapeutic roles in multiple sclerosis and inflammatory bowel disease, was withdrawn from the market after case reports of progressive multifocal leukoencephalopathy in patients receiving this medication.

The cause of all progressive multifocal leukoencephalopathy is reactivation of JC virus (JCV), a widespread papovavirus that initially infects children, leading to latent infection in the kidneys and lymphoid organs. JCV targets myelinating oligodendrocytes of the CNS. PCR of the cerebrospinal fluid for JCV is used for diagnosis in patients with compatible clinical and radiologic findings. HAART for HIV infection is effective when CD4 counts improve to > 100 cells/mcL in improving survival as well as the clinical and radiographic features associated with this disease, although a small number of cases appear to worsen with immune restoration. Other agents used include cidofovir, not routinely recommended, and topotecan, which appears to be of some benefit.

[ArchivalUser]

thanks triple helix . great help . MRI shows multiple demyelinating non enhancing lesions .

next question . what is dejerine roussy syndrome

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any one