pharma # 4 & 5 - kindofblue

[ArchivalUser]

#4
A 31-year-old woman complains of a tremor that affects both hands and has become increasingly bothersome. She says that when she drinks alcohol, the tremor abates for a short period of time. Examination shows an action tremor with a frequency of eight cycles per second. There is no evidence of bradykinesia, rigidity, or postural imbalance. Appropriate therapy for the patient™s neurologic condition would include an agent that blocks

A. α1-adrenergic receptors
B. β2-adrenergic receptors
C. dopamine D2 receptors
D. histamine H2 receptors
E. muscarinic M3 receptors



#5
When an experimental anesthetized subject is treated intravenously with an agonist (drug X), it produces an increase in blood glucose level and in the force of ventricular contraction, and a pronounced decrease in peripheral resistance. Pretreatment of the subject with an antagonist (drug Y) blocks all of these effects. Drug X most likely is which agent?


A. Epinephrine
B. Isoproterenol
C. Norepinephrine
D. Phenylephrine
E. Propranolol

[ArchivalUser]

#4
Option B (β2-adrenergic receptors) is correct. The patient™s symptoms and the effect of alcohol ingestion on them are consistent with benign essential (familial) tremor. The cause of this disorder is not entirely understood, but the activation of β2 receptors (and perhaps β1 receptors) in skeletal muscle is thought to cause alterations in the mechanical properties of muscle and thereby elicit an action tremor. The alterations are believed to be reflected in abnormal discharges of muscle spindle afferent nerves, which modify the timing or activity of the stretch reflex arc. Propranolol, a nonselective β-adrenergic receptor antagonist, is the drug of choice for patients with essential tremor.

#5

Option B (Isoproterenol) is correct. The effects described in the question are mediated by activation of β1- and β2-adrenergic receptors. Isoproterenol is a potent agonist at both receptors, having minimal to no effects on α-adrenergic receptors at therapeutic doses. Intracellularly, its actions are mediated by cyclic adenosine monophosphate (cAMP). The metabolic effects associated with the increase in cAMP cause stimulation of glycogenolysis in the liver and other calorigenic mechanisms, such as release of free fatty acids.

[ArchivalUser]

B. β2-adrenergic receptors

for q 2 the agonist is B2 agonist
is it Isopreternol?

[ArchivalUser]

ok nice and good i knew at least one q!!! bad evening !!

[ArchivalUser]

for the familial tremor, the 1st drug is propranolol, isopreternol is an agonist.