Kaplan ques-please explain also - ramsha

[ArchivalUser]

The reaction catalysed by hepatic phosphofructokinase 1 has a G value of -3.5 kcal/mol. This value indicates that under standard conditions this reaction
A-is reversible
B-occurs very slowly
C-produces an activator of puruvate kinase
D-is inhibited by ATP
E-has a low energy of activation
F-will dec in activity as the ph decreases
G-cannot be used for gluconeogenesis
H-shows cooperative subtrate binding
I-is indirectly inhibited by glucagon
J-is stimulated by fructose 2,6 bisphosphate

[ArchivalUser]

OK ans is G- Now any one can explain why?

[ArchivalUser]

because this value (-3.5 kcal/mol) favors the reaction of the enzyme phosphofructokinase 1 which is an enzyme of glycolysis so it will favor glycolysis and subsequently inhibits gluconeogenesis

[ArchivalUser]

thanks nj_man