questions?? - sakshi

[ArchivalUser]

1.Barriers- blood testis barrier/blood lung/blood brain barriers?? can anyone explain .....please
2.Where exactly do aminoglycosides act to cause nephrotoxicity?(like which part of nephron that gets damaged?)

[ArchivalUser]

Nephrotoxicity results from renal cortical accumulation resulting in tubular cell degeneration and sloughing. Examination of urine sediment may reveal dark-brown, fine or granulated casts consistent with acute tubular necrosis but not specific for aminoglycoside renal toxicity.10 Although serum creatinine levels are frequently monitored during aminoglycoside use, an elevation of serum creatinine is more likely to reflect glomerular damage rather than tubular damage. In most clinical trials of aminoglycosides, however, nephrotoxicity has been defined by an elevation of serum creatinine.5 Periodic monitoring of serum creatinine concentrations may alert the clinician to renal toxicity.

[ArchivalUser]

the source of the article<;

http://www.aafp.org/afp/981115ap/gonzalez.html

hope this helps...

[ArchivalUser]

Thank you.. mohammed92120 .