Codein - mito

[ArchivalUser]

Codein was used for pain and was complaining of constipation. why was his medicine causing the constipation?

[ArchivalUser]

it is an oipiod ...may be µ receptors stimulation?

[ArchivalUser]

katzung///the constipating effects of the opioids are mediated through an action on the enteric nervous system (see Chapter 6) as well as the CNS. In the stomach, motility (rhythmic contraction and relaxation) may decrease but tone (persistent contraction) may increase”particularly in the central portion; gastric secretion of hydrochloric acid is decreased. Small intestine resting tone is increased, with periodic spasms, but the amplitude of nonpropulsive contractions is markedly decreased. In the large intestine, propulsive peristaltic waves are diminished and tone is increased; this delays passage of the fecal mass and allows increased absorption of water, which leads to constipation. The large bowel actions are the basis for the use of opioids in the management of diarrhea.

[ArchivalUser]

Thanks, mohammed92120 and ebnalfady. This is a Tested Q, again.