10-05-2007, 10:28 AM
What is the difference btw them and which one will u prefer 4 a breast Ca patient and why?
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Raloxefene and Tamoxfene - sure
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10-05-2007, 10:35 AM
less Side Effects with raloxifene ( less uterine cancer and thromboembolic events)
10-05-2007, 10:40 AM
yeah thanks. bcos raloxefene does not have stimulatory effect on endometrium receptor. It is also an anti osteoporosis.
10-05-2007, 10:47 AM
yes sure...for osteoporosis i dont know if Raloxifene is better than tamoxifene or if both are equally effective?
10-05-2007, 10:52 AM
http://www.medscape.com/viewarticle/533999
Release Date: June 7, 2006 After a median follow-up of 4 years, there were a similar number of invasive breast cancer cases in both groups (167 with raloxifene vs 163 with tamoxifen). Both drugs reduced the relative risk for breast cancer by about 50% in this patient population. The tamoxifen group had fewer cases of noninvasive breast cancer cases than the raloxifene group (57 vs 81), but more cases of uterine cancer (36 vs 23). Other adverse effects were similar in the 2 groups, except for thromboembolic events, which occurred significantly less often in the raloxifene vs tamoxifen group (100 vs 141 events). "Raloxifene appears on balance to be preferable to tamoxifen," said James Ingle, MD, from the Mayo Clinic in Madison, Wisc, discussant for this presentation at ASCO. Raloxifene had a more favorable risk profile, and as it is already approved for use in postmenopausal osteoporosis, it also has data showing a reduction in fractures from other studies |
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