immunolgy q -

[ArchivalUser]

ss

A 1 yo boy has a scaly eruption on the trunk and scalp,hepatosplenomegaly ,generalised Lymphadenopathy
and osteolytic lession in the skull.A biposy of skin reveals a dermal infiltrate composed of large cells with indented nuclei and foamy cytoplasm.The cells are CD1 ag positive.The cells mosts likely represent

a neutrophils
b.Lymphocytes
c.NK cells
d.histiocytes
e.melanocytes

[ArchivalUser]

xyz - xyz@verizon.com

d.

[ArchivalUser]

kti

yup it is D histiocytes and the dz is histiocytosis.

[ArchivalUser]

ss

yeah
d.histiocytes
Letterer Siwe disease.
Histiocytes are langerhan cells that are CD 1 positive.

[ArchivalUser]

dcsreddy

do u mean to say that this condition is langerhans histiocytosis?

[ArchivalUser]

kti

dcsreddy no this is the lettere siwe dz which is the variatn of histiocytosis X.

[ArchivalUser]

ss

hi dcsreddy ( I referred from Robbins)
Letterer Sewe disease is One of the 3 clinicopathological entities of Langerhans cells Histiocytosis.
other 2 are- Eosinophilic Granulomas and Hand schuller christian disease.
( I referred from Robbins)

[ArchivalUser]

dcsreddy

i am poor in these . can u please expalin in detail ?


good life..dcsreddy