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An oval lesion is found in the right lobe of the liver in an otherwise asymptomatic 24-year-old female. Surgical resection finds a single welldemarcated lesion that has a prominent, central, stellate white scar. This gross appearance is most consistent with a diagnosis of ?
1. Metastatic adenocarcinoma
2. Focal nodular hyperplasia
3. Hemangioma
4. Hepatocellular carcinoma
5. Nodular regenerative hyperplasi
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5? it seems a benign finding.
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The Correct Answer is: Focal nodular hyperplasia
Explanation:
Neoplasms of the liver, either benign or malignant, have characteristic microscopic or gross appearances. Benign tumors of the liver include hemangiomas (the most common), focal nodular hyperplasias, nodular regenerative hyperplasias, and adenomas. Hemangiomas are characterized by numerous small endotheliallined spaces filled with blood. The lack of erythrocytes or blood would raise the possibility of the lesion being a lymphangioma, while pleomorphic or atypical endothelial cells would suggest the possibility of an angiosarcoma. Focal nodular hyperplasia, which has a characteristic gross appearance of a central stellate scar within the tumor, microscopically reveals hepatic nodules surrounded by fibrous bands having numerous proliferating bile ducts. This type of tumor is related to birth-control pills, but has no association with malignancy. In contrast, nodular regenerative hyperplasia involves the entire liver and forms multiple spherical nodules. Histologic sections reveal plump hepatocytes surrounded by rims of atrophic cells. Nodular regenerative hyperplasia is clinically important because it is associated with the subsequent development of portal hypertension. Two types of hepatic adenomas are the liver cell adenoma and the bile duct adenoma. Liver cell adenomas are seen in female patients taking birth-control pills. These adenomas may bleed, but are not associated with malignancy. Histologically, cords of hepatocytes are present, but there is no lobular architecture.
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...very informative explaination,dr kola....thanks.
