pharma q's - drvirgo

[ArchivalUser]

1.how diuretics (loop or thiazides)use can lead to lithium toxicity?
2.why NSAID'S are relatively contraindicated in heart failure?
3.what is the treatment of choice in a neonate opioid withdrawal symptoms born to a mother who is homeless IV drug abuser?
4.which anticonvulsant leads to generalized lymphadenopathy?
5.which antihyperlipidemic and antitubercular drug can precipitate acute gouty attack?

[ArchivalUser]

no one ......................??????????

[ArchivalUser]

1. ??
2. ASA may decrease effects of ACEI (again i dont know how)
3. Diluted tincture of opium and phenobarbital
4. ??
5. Niacin and pyrazinamide

[ArchivalUser]

1) Mecanism? Not sure but I think thiazides may increase lithium toxicity by Li retention.
Thiazides will also increase the risk of digoxin toxicity, due to the hypokalaemia.


4) Phenytoin? dont know

[ArchivalUser]

1]Loop diuretics: May decrease the renal excretion of lithium, leading to toxicity...Thiazide diuretics: May increase serum lithium concentration via sodium depletion and decreased lithium clearance; a lithium dose reduction of 50% is commonly recommended.
2]patients with congestive heart failure, have renal function that is strongly dependent on prostaglandin-mediated blood flow. NSAIDs can inhibit this process and result in further decline. When NSAID therapy diminishes renal function, it can lead to fluid retention, hyperkalemia, and congestive heart failure.
3]tincture of opium
4]phenytoin-Rarely seen effects: SLE-like syndrome, lymphadenopathy, hepatitis, Stevens-Johnson syndrome, blood dyscrasias, dyskinesias, pseudolymphoma, lymphoma, venous irritation and pain, coarsening of facial features, hypertrichosis
5]nicotinicacid and pyrazinamide

[ArchivalUser]

wow kola you are excellent.you have explained everything very well.thanks to others also.hey kola when is your exam.good luck to all.

[ArchivalUser]

mine coming up next week .goodluck to you too.