q90 - ebnalfady

[ArchivalUser]

A patient with intractable itching would best respond to which of the following?
A.
Chlorpromazine
B.
Pimozide
C.
Haloperidol
D.
Risperidone
E.
Clozapine

[ArchivalUser]

A??
NO idea...no antihistaminic mentioned..?

[ArchivalUser]

e.
It blochs histamine receptors. but not sure.

[ArchivalUser]

aaaaa

[ArchivalUser]

The answer is: A

Agents with H1 receptor blocking actions are effective in reducing itching. H1 receptor blockade is typical of phenothiazines with short side chains.

[ArchivalUser]

ebnalfady, i think theres a mistake in this question, theres no H1 block in chlorpromazine, i think they meant Clomipramine

[ArchivalUser]

ys,rt smiles11,shd b chlomipramine

[ArchivalUser]

i think its Chlorpheniramine,,,,H1 blocker

Chlorpromazine,,,antipsychotic

Clomipramine,,,,TCA

[ArchivalUser]

this what katzung write
Pharmacologic Effects

The first phenothiazine antipsychotic drugs, with chlorpromazine as the prototype, proved to have a wide variety of central nervous system, autonomic, and endocrine effects. These actions were traced to blocking effects at a wide range of receptors, including dopamine and adrenoceptor, muscarinic, H1 histaminic, and serotonin (5-HT2) receptors. Dopamine receptor effects quickly became the major focus of interest.

[ArchivalUser]

i second ebnalfady........chorpromazine does has anti-histaminic action, thats why it has use as anti-emetic.....and side-effect of sedation