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Patho-1 - shiney
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03-21-2008, 07:27 AM
A crisis in a patient with sickle cell disease is
most likely to be caused by (A) alkalosis (B) acidosis © increased oxygen concentration (D) decreased CO2 concentration (E) decreased 2,3-bisphosphoglycerate concentration
03-21-2008, 07:43 AM
yep u all rt.
a crisis in sickle cell disease occurs when deoxygenated HbS precipitates, deforming (sickling) red blood cells and blocking capillaries. Variables that increase the proportion of ribS in the "deoxy" state tend to increase the probability of a crisis by increasing the extent of sickling. The "deoxy" form of hemoglobin is favored by a decrease in pH (acidosis).
03-21-2008, 07:51 AM
sure,okt3
 An increase in pH (alkalosis), increased oxygen concentration, decreased CO2 concentration, and decreased 2,3-bisphospho- glycerate concentration would all favor the "oxy"
03-21-2008, 07:53 AM
It cant be E. Decrease 2,3 DPG will cause a left shift of the Oxygen dissociation curve which will decrease oxygen release from Haemoglobin and thus prevent sickling of the red blood cell beacuse the Oxygen saturation is higher.
Basics as always. |
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