NBME 5 IMMUNOLOGY GVHD question - bhanusupriya

[ArchivalUser]

In organ transplantation GVHD may be induced by donor T -lymphocytes.which of the following disease specific organ transplants is most likely to derive some benefit from this GVH Response.
1] Bone marrow transplant for acute myelogenous leukemia
2] Heart transplant for viral cardio myopathy
3] Islet cell transplant for type 1 DM
4] Kidney transplant for membranous glomerulonephritis
5] Lung transplant for primary pulmonory hypertension

plz post ur explanation too.....

[ArchivalUser]

a. because the donor lymphocytes will also attack leukemic cells

[ArchivalUser]

In AML, host's immunity is reduced with reduced number of funtioning WBCs. So the donor lymphocytes will invade the host and induce a GVH disease.

In rest of the options provided, host's immunity is normal.

[ArchivalUser]

thank you very much stenosis and paddy...