05-26-2008, 11:47 AM
and looks interesting to me, just wanna share it with you
The intervention that has most consistently prolonged life span in most species is calorie restriction. Recently, it has been proposed that calorie restriction imposes a level of stress that activates proteins of the Sirtuin family, such as Sir2, that function as histone deacetylases. These proteins may deacetylate and thereby activate DNA repair enzymes, thus stabilizing the DNA; in the absence of these proteins, DNA is prone to damage.
From Kumar. Robins Basic Pathalogy 8th ed.
The intervention that has most consistently prolonged life span in most species is calorie restriction. Recently, it has been proposed that calorie restriction imposes a level of stress that activates proteins of the Sirtuin family, such as Sir2, that function as histone deacetylases. These proteins may deacetylate and thereby activate DNA repair enzymes, thus stabilizing the DNA; in the absence of these proteins, DNA is prone to damage.
From Kumar. Robins Basic Pathalogy 8th ed.