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A 7-year-old white female - rehellohie
#1
A 7-year-old white female is brought to your office because of a 3-day history of an increasingly clumsy gait. The mother noted that she first observed the problem 2 days earlier when her daughter climbed out of the bathtub and had difficulty standing up while being dried off. At the time she thought the child was just playing. The next day the child seemed better and went to school, but was sent home because she was having difficulty on the playground and said that "it was hard" going up the stairs. The child had a minor upper respiratory illness, as did other family members, but otherwise was not particularly sick. However, on the morning of this office visit, the child was unable to stand up when she got out of bed and had difficulty using her spoon to eat her cereal. She had no difficulty swallowing.

Examination is within normal limits, except for a slightly runny nose which drains clear, watery mucus. There is no evidence of ear infection or sinusitis. She has profound weakness (but not total paralysis) of the lower extremities, and to a lesser extent, the upper extremities. There is no sensory deficit and no difficulty with urination.

never having had any similar symptoms. The family lives in a rural area near woods; she has two older brothers. Family pets include two dogs, a cat, and a parakeet. No family members or animals are sick. Blood counts, chemistries, urinalysis, cerebrospinal fluid, a CT scan of the head, and a chest roentgenogram are all normal. A tick is found in her scalp.

Which one of the following statements is true concerning this patient's condition?



a. The most likely diagnosis is tick paralysis; the tick should be removed and the patient followed
b. Since the patient had progressive symptoms for 3 to 4 days, removing the tick at this point will probably not lead to total recovery
c. Tick paralysis is fatal to the majority of patients
d. The paralysis is caused by a toxin produced by Babesia microti
e. Treatment includes physical therapy and broad-spectrum antibiotics

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#2
a.

tick paralysis...sxs usually appear 5-7 days after the tick attaches it self to the host.
good question.

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#3
Tick paralysis occurs when an engorged and gravid (egg-laden) female tick produces a neurotoxin in its salivary glands and transmits it to its host during feeding. Experiments have indicated that the greatest amount of toxin is produced between the fifth and seventh day of attachment (often initiating or increasing the severity of symptoms), although the timing may vary depending on the species of tick.
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#4
Unlike Lyme disease, ehrlichiosis, and babesiosis, which are caused by the systemic proliferation and expansion of parasites in their hosts long after the offending tick is gone, tick paralysis is chemically induced by the tick and therefore usually only continues in its presence.
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#5
Treatment

Removal of the embedded tick usually results in resolution of symptoms within several hours to days. If the tick is not removed, the toxin can be fatal, with reported mortality rates of 10“12 percent,[4] usually due to respiratory paralysis. The tick is best removed by grasping the tick as close to the skin as possible and applying firm steady pressure.[
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#6
Tick paralysis is believed to be due to toxins found in the tick's saliva that enter the bloodstream while the tick is feeding. The two ticks most commonly associated with North American tick paralysis are the Rocky Mountain wood tick (Dermacentor andersoni) and the American dog tick (Dermacentor variabilis)
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#7
Prevention

No vaccine is currently available for any tick-borne disease, except for Tick-borne encephalitis. Individuals should therefore take precautions when entering tick-infested areas, particularly in the spring and summer months. Preventive measures include avoiding trails that are overgrown with bushy vegetation, wearing light-colored clothes that allow one to see the ticks more easily, and wearing long pants and closed-toe shoes. Tick repellents containing DEET (N,N, diethyl-m-toluamide) are only marginally effective and can be applied to skin or clothing. Rarely, severe reactions can occur in some people who use DEET-containing products. Young children may be especially vulnerable to these adverse effects. Permethrin, which can only be applied to clothing, is much more effective in preventing tick bites. Permethrin is not a repellent but rather an insecticide; it causes ticks to curl up and fall off of the protected clothing.
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#8
nice question rehellohie..thnks..
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#9
showman -- thats nice explaination.
I have explaination but thats not so comprehensive. thanx
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#10
whoa! thanks rehellohie and showman.......
good question and excellent explaination.
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