glucagon increases insulin....why so... - helpme4usmle1

[ArchivalUser]

hi guys, how does glucagon increase insulin. i thought we gave glucagon in hypoglycemia...wats the concept here guys...

[ArchivalUser]

I never heard of that. Where did you read it?

[ArchivalUser]

there is nothing new guys its indirect effect of glycagon. infact glucagon increases blood glucose ---> than incraese blood glucose it self is the trigger for insulin release. this is how glcagin effect insulin release. dont think that glucagon has any direct effect on beta cell.

[ArchivalUser]

Islet cell hormones have local or paracrine effect as well as endocrine action. Insulin's paracrine effect is to inhibit glucagon secretion, while glucagon's effect is to increase insulin secretion.
On a molecular level, Glucagon activates phospholipase C (Gq) to increase intracellular Calcium, which to release of insulin.

[ArchivalUser]

glucagon being gut hormone do release insulin,via locally stimulating beta cells-->insulin and it makes sense too,glucose being made by glycogenlysis etc under glucagon action,if no insulin how cells gonna take/use glucose????????which only insulin can via glut.