Renal disease dose adjustment. - guest78

[ArchivalUser]

Three long-term nursing-home residents have developed influenza, although all residents were recently immunized against this virus. A decision is made to administer a prophylactic antiviral agent to all residents at this time. One 86-year-old woman, who is otherwise healthy, had the following laboratory results during routine testing 1 week ago:

Laboratory Studies
Hemoglobin

10 g/dL (100 g/L)
Leukocyte count

4500/μL (4.5 × 109/L)
Serum creatinine

2.5 mg/dL (221.05 µmol/L)
Serum uric acid

2.0 mg/dL (0.12 µmol/L)
Serum alkaline phosphatase

350 U/L
Serum aminotransferases

Normal

Which of the following antiviral agents would require dosage adjustment in this patient?



A Amantadine
B Zanamivir
C Oseltamivir
D Rimantadine

[ArchivalUser]

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[ArchivalUser]

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[ArchivalUser]

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[ArchivalUser]

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[ArchivalUser]

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[ArchivalUser]

a..

[ArchivalUser]

Oseltamivir

[ArchivalUser]

a

[ArchivalUser]

ans is AAA

Because amantadine is excreted by the kidneys, dosage adjustment is required in patients with renal compromise. Although oseltamivir and zanamivir are also excreted by the kidneys, these agents do not require dose adjustment when used as prophylaxis in renal-compromised patients. Rimantadine is metabolized by the liver and therefore does not require a change in dose