01-03-2009, 07:18 AM
A 34 year old female presents to her primary care physician with a variety of complaints that have started over the past couple couple of years and that seem to be increasing in severity. She states that a couple of winters ago, her fingers with become painful and blue when she went outside without gloves. She has also had pain in her elbows and knees that sometimes responds to ibuprofen. Most recently she has notice a purple rash on her face most prominent above her eyes. She denies muscle weakness, difficultly swallowing, palpitations or fever.
On exam, she is in no distress with normal vitals signs. Her lung examination is notable for a rubbing sounds, but the rest of her exam is within normal limits.
Which of the following antibodies is most specific for her disease?
A. Anti-Jo Ab
B. Anti-SCL-70 Ab
C. Anti-U1-RNP Ab
D. Anti-centromere Ab
E. Anti-ds DNA Ab
On exam, she is in no distress with normal vitals signs. Her lung examination is notable for a rubbing sounds, but the rest of her exam is within normal limits.
Which of the following antibodies is most specific for her disease?
A. Anti-Jo Ab
B. Anti-SCL-70 Ab
C. Anti-U1-RNP Ab
D. Anti-centromere Ab
E. Anti-ds DNA Ab