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43-year-old man amitryptiline use - hopeofglory87
#1
A 43-year-old man with a history of alcohol abuse comes to the clinic seeking a refill of amitriptyline, 150 mg, which has helped him with his neck pain. He claims that he was prescribed this medication by a physician after being discharged from the psychiatric hospital. He needs this specific medication because, aside from reducing the neck pain, it helps with his depression and therefore helps to decrease the amount of alcohol he consumes. He is otherwise very vague about the previous psychiatric history, even though he admits that he was hospitalized several times, mostly because of his drinking. He was treated with haloperidol and some other medications such as lithium and carbamazepine. He claims not to remember what his diagnosis was. He has a remote history of trouble with erection and ejaculation. During the interview, he denies being euphoric but admits to having racing thoughts. His speech is a little pressured. He becomes quite irritable and loud when the physician asks more questions. Which of the following factors in this patientâ„¢s history would preclude prescribing amitriptyline at this time?

A. Alcohol abuse history
B. Neck-pain history
C. Racing thoughts and pressured speech
D. Possible liver damage secondary to alcohol
E. Sexual side effects
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#2
c as it may precipitate mania
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#3
cc
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#4
yep C agree
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#5
whats the diagnosis guys
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#6
yes C..

he probably had bipolar disorder type I
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#7
Good u guys

The correct answer is C. This patient has racing thoughts and pressured speech, is irritable, and has a history of alcohol abuse and treatment with lithium, which indicate the strong possibility of bipolar disorder. Amitriptyline may actually switch him to a manic state. He would need to be on a mood stabilizer first and then prescribed an antidepressant, possibly one with the lowest potential for inducing mania, such as bupropion.
Alcohol abuse history (choice A) per se is not a contraindication for the use of tricyclic antidepressants. There are, however, other, safer ones nowadays with more tolerable side effects.
Neck-pain history (choice B) would be an indication for low doses of tricyclics in order to reduce pain.
Possible liver damage (choice D) is not an absolute contraindication for the use of tricyclics, even though one should consider alternatives and dosages because of their liver metabolism.
Sexual side effects (choice E) accompany the use of tricyclics, but in this case the patient demands to have the medication anyway
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#8
nice question, thanksSmile
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#9
http://www.usmleforum.com/showthread.php?tid=328144
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#10
i got the idea but what does amytriptilline do that precipitates the mania attack????

hmmm?
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