02-20-2009, 12:45 PM
A 5-year-old boy presents to his pediatrician because his mother notices that he has been
complaining of fatigue and headache for several weeks. On examination, he is found to
have enlarged lymph nodes and is sent for a bone marrow biopsy. The biopsy shows large
lymphoblasts with prominent nucleoli and light blue cytoplasm, and the patient is diagnosed
with acute lymphoid leukemia. He is treated with high-dose glucocorticoids, intravenous
and intrathecal methotrexate, cyclophosphamide, doxorubicin, and vincristine. He achieves a full remission.
Which of the following accurately matches the causative drug with the possible side effect that he may experience now or in the future?
A) Cyclophosphamide: hearing loss
B) Glucocorticoids: cataracts
C) Glucocorticoids: peripheral neuropathy
D) Methotrexate: cognitive deficit
E) Methotrexate: pulmonary fibrosis
complaining of fatigue and headache for several weeks. On examination, he is found to
have enlarged lymph nodes and is sent for a bone marrow biopsy. The biopsy shows large
lymphoblasts with prominent nucleoli and light blue cytoplasm, and the patient is diagnosed
with acute lymphoid leukemia. He is treated with high-dose glucocorticoids, intravenous
and intrathecal methotrexate, cyclophosphamide, doxorubicin, and vincristine. He achieves a full remission.
Which of the following accurately matches the causative drug with the possible side effect that he may experience now or in the future?
A) Cyclophosphamide: hearing loss
B) Glucocorticoids: cataracts
C) Glucocorticoids: peripheral neuropathy
D) Methotrexate: cognitive deficit
E) Methotrexate: pulmonary fibrosis