05-19-2009, 03:31 PM
A 30 year-old man comes to medical attention because of fevers and night sweats. CT scan reveals masses involving the mediastinal nodes, abdominal nodes, and liver. Biopsy of one of the nodes demonstrates a nodular lymphoma with nodular areas composed predominately of small (6-12 micrometer) lymphocytes with scanty cytoplasm and irregular, twisted, and indented nuclei. This lymphoma is most closely linked to a translocation involving which of the following?
A. Immunoglobulin heavy chain and bcl-1.
B. Immunoglobulin heavy chain and bcl-2.
C. Immunoglobulin heavy chain and myc.
D. Kappa immunoglobulin light chain and myc.
E. Lambda immunoglobulin light chain and myc.
A. Immunoglobulin heavy chain and bcl-1.
B. Immunoglobulin heavy chain and bcl-2.
C. Immunoglobulin heavy chain and myc.
D. Kappa immunoglobulin light chain and myc.
E. Lambda immunoglobulin light chain and myc.