05-25-2009, 01:38 PM
according 2 fa &kaplan it,s in nucleus but uw said it,s in cytoplasm what,s correct
7methylG capping in nucleus or cytopolasm - laiba07
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05-25-2009, 01:38 PM
according 2 fa &kaplan it,s in nucleus but uw said it,s in cytoplasm what,s correct
05-25-2009, 01:59 PM
i thought it was in nucleus
05-25-2009, 02:00 PM
bc it gets spliced in cyto from pre-mrna to mrna
05-25-2009, 02:16 PM
capping--- one of the post transcriptional modification process
has 2 steps' 1st.....>addition of GTP-- GTP+ 5'end of mRNA------by Guanayl tranferase......>5'guanasine cap--occurs in NUCLEUS 2nd---->methylation', methylation+5'G.cap---by guanasine 7 methyl transferase(SAM).....>5'methylated guanasine cap....occurs in CYTOPLASM..
05-25-2009, 02:39 PM
thanx ksstep ,dr bkc where can i find this cytoplasmic posttrascriptional modificationb/c my concept was transcription completed in nucleus and translation occur in cytoplasm .found alternative splicing eg variants of tropomyosin &troponin,synthysis of memb bound Ig vs secreted Ig, DAreceptor i n brain made from 1 gene(kaplan bio chapter 3)
05-25-2009, 02:42 PM
u can see ..lippincot biochem..
add one more Example for alternative splicing product s FIBRONECTIN |
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