what does it mean that Wrfarin is p450 deependant - paracrine

[ArchivalUser]

does it mean that it inhibits or enhance it guys, i have a doubt

[ArchivalUser]

nimish do you know?

[ArchivalUser]

warfarin metabolised by cyp450,so drug which compete for metabolism increse dose,drug which inhibit metabolism increse dose
drug which induce cyp450 decrese dose
correction plz

[ArchivalUser]

ok tks,
what are some other example of dependants one? I dont mean inducers and inhibitors I do remember those. I mean like warfarin , OCP, what else?

[ArchivalUser]

its very hard as all drugs are affected by it
but important are ocps/warfarin/antiepileptics/ssri/antiaarrythmatics/antihiv to watch for

[ArchivalUser]

tks you are awesome

[ArchivalUser]

important drug interaction with Warfarin is

Cimitidine, Amiodarone--increase warfarin level.

Rifampin, St John's wort--decrease warfarin level.